POINTWISE MUTUAL INFORMATION QUANTIFIES INTRATUMOR HETEROGENEITY IN TISSUE SECTIONS LABELED WITH MULTIPLE FLUORESCENT BIOMARKERS

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy.Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to heterogeneity.Methods: We demonstrate how to quantify

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A new approach in philosophy of education

Philosophy is the method of correct thinking, the way of wise living, and the effort for understanding the existence.We face a diverse range of philosophies such as philosophy of religion, philosophy of art, philosophy of science, philosophy of various sciences, and philosophy of education.It is this philosophy of education which is the subject of

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A Comparison of Provision and Access to Inclusive Education for Children with Disabilities in a Metropolitan City and a Rural District in Telangana State, India

In response to international agreements, recent Indian legislation has raised expectations that all children, regardless of need or ability, should gain access to formal education that is inclusive and addresses their social and learning needs.Initiatives designed to support the implementation of this legislation have been undertaken in several par

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